Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

FEBS Letters

Djiane, J.²  Kelly, P.A.¹  Petridou, B.²  Thoreau, E.³  Mornon, J.P.³ 

[1] Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, 687 Pine Ave West, Montreal H3A 1A1, Canada;Unite d'Endocrinologie Moléculaire, Batiment des Biotechnologies, INRA, 78350 Jouy en Josas, France;Groupe Cristallographie et Simulations Interactives des Macromolécules biologiques, Laboratoire de Mineralogie-Cristallographie, Universités Paris VI et Paris VII, CNRS URA 09, T16, 4 place Jussieu, 75252 Paris Cedex 05, France

关键词: Cytokine;    Protein sequence comparison;    Protein structure prediction;    Immunoglobulin superfamily;    Fibronectin;    Contactin;   

DOI  :  10.1016/0014-5793(91)80437-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sequence comparison based on Hydrophobic Cluster Analysis procedures shows that the extracellular ≈ 200 amino acids domains of cytokines receptors belonging to the Cytokine/Growth hormone/Prolactin receptor family and to the Interferon one are organized in two homologous subdomains. Further, comparison of the subdomains of 32 independent sequences and of a lot of already recognized homologous domains with data bases could lead to the hypothesis that these ≈ 100 amino acids subdomains could possess the overall fold of the constant immunoglobulin domains and so could belong to the immunoglobulin superfamily.

【 授权许可】

Unknown