Ethanol has an acute effect on bile acid biosynthesis in man

FEBS Letters

Axelson, Magnus¹  Mörk, Birgitta²  Sjövall, Jan² 

[1] Department of Clinical Chemistry, Karolinska Hospital, S-10401 Stockholm, Sweden;Department of Physiological Chemistry, Karolinska Institutet, S-10401 Stockholm, Sweden

关键词: Alcohol;    Bile acid;    Cholesterol;    Human;    Blood;   

DOI  :  10.1016/0014-5793(91)80382-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A single dose of ethanol, 0.4 g/kg body weight, was found to give a 5–15 fold increase of the plasma concentrations of 7α-hydroxy-cholesterol and 7α-hydroxy-4-cholesten-3-one in humans. The rise was maximal 4 h after ethanol ingestion, was dose-dependent and was not seen in a cholecystectomized subject. The effect was selective for these and some other 7α-hydroxylated C₂₇-intermediates in bile acid bioxynthesis. The changes are compatible with an acute stimulation of cholesterol 7α-hydroxylase possibly due to an ethanol-induced inhibition of gallbladder contraction resulting in an interruption of the enterohepatic circulation of bile acids. The effect is of interest in relation to the influence of ethanol consumption on cardiovascular and gallstone diseases.

【 授权许可】

Unknown