Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

FEBS Letters

Miñana, Maria-Dolores¹  Felipo, Vicente¹  Grisolía, Santiago¹ 

[1] Instituto de Investigaciones Citològicas de la Caja de Aharros de Valencia, Centro Asociado del CSIC, Amadeo de Saboya 4, 46010 Valencia, Spain

关键词: Neuritogenesis;    Protein kinase C;    Actinomycin D;    Neuroblastoma;   

DOI  :  10.1016/0014-5793(91)80302-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have previously reported that inhibition of protein kinase C induces differentiation of neuroblastoma cells in culture. It is shown now that actinomycin D, a well known inhibitor of DNA synthesis, reduces selectively the content of protein kinase C and induces neuritogenesis in Neuro 2a cells in culture.

【 授权许可】

Unknown