Modulation of a Shaker potassium A‐channel by protein kinase C activation

FEBS Letters

Dascal, Nathan¹  Moran, Ofira¹  Lotan, Ilana¹ 

[1] Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel

关键词: Potassium channel;    Modulation;    Protein kinase C;    Activation;    Inactivation;   

DOI  :  10.1016/0014-5793(91)80162-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Brain fast transient K??? channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effects is a small change in the voltage-dependence of activation and inactivation of the channel.

【 授权许可】

Unknown