期刊论文详细信息
FEBS Letters | |
ATP‐sensitive K channels in heart muscle Spare channels | |
Faivre, Jean-François1  Findlay, Ian1  | |
[1] Laboratoire de Physiologie Comparée (URA CNRS 1121), Université de Paris XI, Orsay, France | |
关键词: K channel; Ligand sensitivity; ATP; Rat ventricular muscle; | |
DOI : 10.1016/0014-5793(91)80259-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We show that ATP-sensitive K+ channels of excised inside-out membrane patches of rat ventricular myocytes show considerable variation in their sensitivity to ATP. In 102 different membrane patches IC50 values ranged from 9 to 580 μM ATP and Hill coefficient from 1% to 6.41% of patches showed openings of ATP-sensitive K+ channels in the presence of 1 mM ATP. These results considerably widen the range of internal ATP concentrations over which one might expect activation of the ATP-sensitive K+ current in cardiac myocytes.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020294471ZK.pdf | 344KB | download |