ATP‐sensitive K channels in heart muscle Spare channels

FEBS Letters

Faivre, Jean-François¹  Findlay, Ian¹ 

[1] Laboratoire de Physiologie Comparée (URA CNRS 1121), Université de Paris XI, Orsay, France

关键词: K channel;    Ligand sensitivity;    ATP;    Rat ventricular muscle;   

DOI  :  10.1016/0014-5793(91)80259-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We show that ATP-sensitive K⁺ channels of excised inside-out membrane patches of rat ventricular myocytes show considerable variation in their sensitivity to ATP. In 102 different membrane patches IC₅₀ values ranged from 9 to 580 μM ATP and Hill coefficient from 1% to 6.41% of patches showed openings of ATP-sensitive K⁺ channels in the presence of 1 mM ATP. These results considerably widen the range of internal ATP concentrations over which one might expect activation of the ATP-sensitive K⁺ current in cardiac myocytes.

【 授权许可】

Unknown