Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin‐secreting β‐cell line, HIT T15

FEBS Letters

Ashcroft, S.J.H.¹  Rorsman, P.²  Trube, G.⁵  Berggren, P.O.³  Welsh, M.⁴  Betzholz, C.⁷  Ashcroft, Frances M.⁶ 

[1] Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, England;Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG;Department of Endocrinology, Karolinska Institute, Stockholm, Sweden;Department of Medical Cell Biology, Uppsala University, Sweden;Department of Medical Physics, Gothenburg, Sweden;University Laboratory of Physiology, Oxford, England;Department of Pathology, Uppsala University, Sweden

关键词: ATP-sensitive K channel;    K channel;    (Pancreatic β-cell);   

DOI  :  10.1016/0014-5793(88)80913-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A⁺) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from β-cells.

【 授权许可】

Unknown