FEBS Letters | |
Cloning and chromosomal assignment of a widely expressed human receptor‐like protein‐tyrosine phosphatase | |
Harder, Kenneth W.1  Janzen, Nicole M.1  Melhado, Ian G.1  Jirik, Frank R.1  | |
[1] The Biomedical Research Center, University of British Columbia, Vancouver, BC V6T 1W5, Canada | |
关键词: Protein-tyrosine phosphatase; Human chromosome 20; Protein phosphorylation; Hep G2 cell; PTPase; protein-tyrosine phosphatase; PTK; proteintyrosine kinase; | |
DOI : 10.1016/0014-5793(90)81094-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Insight into the regulation of the actions of the protein-tyrosine kinases will be greatly facilitated by the full characterization of the family of protein-tyrosine phosphatases. A search for novel phosphatases resulted in the isolation of a cDNA, termed HLPR, encoding a member of the family of human receptor-like protein-tyrosine phosphatases: its cDNA sequence predicts a protein of 793 amino acids (unglycosylated M r, 87500) and includes a 121 residue extracellular domain, a single transmembrane segment, and two tandem intra-cytoplasmic catalytic domains. The HLPR gene is located on human chromosome 20, and the protein it encodes likely plays a fundamental role in the physiology of all cells as its expression appears to be ubiquitous.
【 授权许可】
Unknown
【 预 览 】
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RO201912020294099ZK.pdf | 560KB | download |