Cloning and chromosomal assignment of a widely expressed human receptor‐like protein‐tyrosine phosphatase

FEBS Letters

Harder, Kenneth W.¹  Janzen, Nicole M.¹  Melhado, Ian G.¹  Jirik, Frank R.¹ 

[1] The Biomedical Research Center, University of British Columbia, Vancouver, BC V6T 1W5, Canada

关键词: Protein-tyrosine phosphatase;    Human chromosome 20;    Protein phosphorylation;    Hep G2 cell;    PTPase;    protein-tyrosine phosphatase;    PTK;    proteintyrosine kinase;   

DOI  :  10.1016/0014-5793(90)81094-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Insight into the regulation of the actions of the protein-tyrosine kinases will be greatly facilitated by the full characterization of the family of protein-tyrosine phosphatases. A search for novel phosphatases resulted in the isolation of a cDNA, termed HLPR, encoding a member of the family of human receptor-like protein-tyrosine phosphatases: its cDNA sequence predicts a protein of 793 amino acids (unglycosylated M _r, 87500) and includes a 121 residue extracellular domain, a single transmembrane segment, and two tandem intra-cytoplasmic catalytic domains. The HLPR gene is located on human chromosome 20, and the protein it encodes likely plays a fundamental role in the physiology of all cells as its expression appears to be ubiquitous.

【 授权许可】

Unknown