期刊论文详细信息
FEBS Letters | |
In vitro studies on origin and site of action of enzyme activity responsible for conversion of human proapoprotein A‐I into apoprotein A‐I | |
Louis, Havekes1  Kooistra, Teake1  Victor, van Hinsbergh1  Herman Jan, Kempen1  | |
[1] Gaubius Institute, Health Research Division TNO, Herenstraat 5d, 2313 AD Leiden, The Netherlands | |
关键词: Human proapolipoprotein A-I; Hep G2 cell; Endothelial cell; HDL metabolism; apo; apolipoprotein; HDL; LDL and VLDL; high density; low density and very low density lipoprotein; respectively; LPDS; lipoprotein-depleted serum; ECGS; endothelial cell growth supplement; EGF; epidermal growth factor; BSA; bovine serum albumin; | |
DOI : 10.1016/0014-5793(84)81379-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Human hepatocellular carcinoma cells (Hep G2) were shown to secrete apo A-I as a proprotein. No apo A-I synthesis could be detected with endothelial cells from human umbilical cord veins. Conversion of proapo A-I into apo A-I is a slow (of the order of hours) process, mediated by a Ca2+/Mg2+-dependent enzyme which is present on the surface of plasma lipoprotein particles, endothelial cells and Hep G2 cells, and is probably synthesized by Hep G2 cells.
【 授权许可】
Unknown
【 预 览 】
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RO201912020285437ZK.pdf | 481KB | download |