Molecular cloning of a novel G protein‐coupled receptor that may belong to the neuropeptide receptor family

FEBS Letters

Sprengel, Rolf¹  Keinänen, Kari¹  Monyer, Hanna¹  Seeburg, Peter¹  Eva, Carola¹ 

[1] Zentrum für Molekulare Biologie Heidelberg, University of Heidelberg, Heidelberg, FRG

关键词: G protein receptor;    Tachykinin receptor;    Neuropeptide receptor;   

DOI  :  10.1016/0014-5793(90)80377-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel cDNA encoding a putative G protein-coupled receptor was isolated from a rat forebrain cDNA library by homology screening. Sequence comparison demonstrates that the encoded polypeptide containing seven transmembrane domains shows highest homology with tachykinin receptors, particularly in the transmembrane domains and the first intracellular loop. The mRNA for this new receptor seems specifically expressed in brain and is prominently localized in specific nuclei of the rat brain, including thalamus, cerebral cortex and hippocampus. We speculate that a neuropeptide may be the natural ligand of this novel G protein-coupled receptor.

【 授权许可】

Unknown