mRNA acetylated at 2'‐OH‐groups of ribose residues is functionally active in the cell‐free translation system from wheat embryos

FEBS Letters

Alakhov, Yu.B.¹  Ovodov, S.Yu.¹ 

[1] Institute of Protein Research, Academy of Sciences of the USSR, 142292 Pushchino, Moscow Region, USSR

关键词: Template ribonucleic acid;    Chemical modification;    Translation;    in vitro;   

DOI  :  10.1016/0014-5793(90)81246-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Modification (acetylation) of 2'-OH groups of mRNA ribose residues does not result in a loss of their template activity in a cell-free translation system from wheat embryos and in some cases activates inactive mRNAs. Modification of 70–75% of 2'-OH groups makes mRNA stable to the effect of pancreatic ribonuclease.

【 授权许可】

Unknown