Overexpression of glucose transporter modulates insulin biosynthesis in insulin producing cell line

FEBS Letters

Oka, Y.¹  Shibasaki, M.²  Kajio, H.²  Takaku, F.¹  Asano, T.²  Akanuma, Y.²  Shibasaki, Y.¹ 

[1] The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113, Japan;The Institute for Diabetes Care and Research, Asahi Life Foundation 1-6-1 Marunouchi, Chiyoda, Tokyo 100, Japan

关键词: Glucose transporter;    Insulin biosynthesis;   

DOI  :  10.1016/0014-5793(90)81244-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose transporter (GT) has been suggested to be involved in the insulin biosynthesis. However, the functional relationship between GT and insulin biosynthesis is not well understood. In this report, we have generated rat pancreatic B cell lines (RINr) that stably overexpress a cDNA encoding the brain type GT. These cell lines showed 3- to 4-fold increase in insulin mRNA and protein. These results suggest that GT might have some relationship to the insulin biosynthesis in the pancreatic B cells.

【 授权许可】

Unknown