Regulation of the Na+ ‐K+ pump activity and estimation of the reserve capacity in intact rat peritoneal mast cells

FEBS Letters

Johansen, T.¹  Knudsen, T.¹ 

[1] Institute of Medical Biology, Department of Pharmacology, Odense University, J.B. Winsløws Vej 19, DK-5000 Odense C, Denmark

关键词: Mast cell;    Na+ -K+ pump;    Na+;    -K+-ATPase;    Sodium;    Potassium;   

DOI  :  10.1016/0014-5793(90)81105-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is provided that regulation of the Na⁺ -K⁺ pump activity in rat peritoneal mast cells occurs mainly through stimulation of the pump from inside the plasma membrane by sodium. It is demonstrated that there is a large reserve capacity for the exchange of intracellular sodium with extracellular potassium in these cells. The maximal pump activity was estimated to be 3230 cells per min and K _m for extracellular potassium was 1.5 mM.

【 授权许可】

Unknown