The signal transduction induced by thrombin in human platelets

FEBS Letters

Lapetina, Eduarde G.¹ 

[1] Cell Biology Division, Burroughs Wellcome Co., Research Triangle Park, NC 27709, USA

关键词: Heterotrimeric G protein;    Small molecular weight G protein;    Phospholipase C;    Phospholipase A2;    3-inositol phospholipid;    Protein kinase A;   

DOI  :  10.1016/0014-5793(90)81293-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Stimulation of human platelets by thrombin leads to the activation of phospholipases C and A₂, protein kinases, formation of 3-inositol phos- pholipids and mobilization of Ca²⁺ . These biochemical reactions closely parallel platelet shape change, granular secretion and aggregation. The membrane-bound transducers for the thrombin receptor seem to be the heterotrimeric G protein G₁₂ and the ras-related G protein rap 1-b. Phosphorylation of rap 1-b by the action of the cyclic AMP-dependent protein kinase seems to uncouple the thrombin receptor from phospholipases. This causes inhibition of the formation of second messenger molecules and the onset of physiological responses.

【 授权许可】

Unknown