Induction of ornithine decarboxylase by treatment of guinea pig lymphocytes with phospholipase C

FEBS Letters

Otani, Shuzo¹  Kuramoto, Ayako¹  Matsui, Isao¹  Morisawa, Seiji¹ 

[1] Department of Biochemistry, Osaka City University Medical School, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan

关键词: Ornithine decarboxylase;    Phospholipase C;    Phospholipase A2;    Lymphocytes;    Clostridium perfringens;    Naja naja snake venom;    ODC;    ornithine decarboxylase [L-ornithine carboxylase;    EC 4.1.1.17];   

DOI  :  10.1016/0014-5793(83)80076-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Treatment of guinea pig lymphocytes with Clostridium perfringens phospholipase C but not with Naja naja snake venom phospholipase A₂ increased ornithine decarboxylase activity. The increase in ornithine decarboxylase activity was suppressed by actinomycin D or cycloheximide, suggesting that de novo syntheses of RNA and protein are necessary for the increase in the enzyme activity. These results suggest that the activation of phospholipase C rather than that of phospholipase A₂ is responsible for induction of ornithine decarboxylase during lymphocyte transformation.

【 授权许可】

Unknown