Neurotransmitter release

FEBS Letters

Zimmermann, Herbert¹ 

[1] AK Neurochemie, Zoologisches Institut der J.W. Goethe-Universität,Siesmayerstr. 70, D-6000 Frankfurt am Main, FRG

关键词: Exocytosis;    Neurotransmitter;    Protein kinase C;    Release: Synapse;    Vesicle;   

DOI  :  10.1016/0014-5793(90)81292-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron-lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron-dense granules store and release proteins and peptides. Release of the two types of substances underlies different physiological control. Release of messenger molecules from axon terminals is triggered by influx of Ca²⁺ through voltage sensitive Ca²⁺ channels and a rise in cytosolic Ca²⁺ concentrations. Neither the immediate Ca²⁺ target(s) nor the molecular species involved in synaptic vesicle docking, fusion and retrieval are known. It is, however, likely that steps involved in the molecular cascade of transmitter release include liberation of vesicles from their association with the cytonet and phosphorylation by protein kinase C of proteins which have the ability to alter between membrane bound and cytoplasmic forms and thus facilitate or initiate the molecular interaction between synaptic vesicles and the plasma membrane.

【 授权许可】

Unknown