The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

FEBS Letters

Knight, D.E.¹  Baker, P.F.¹ 

[1] Department of Physiology, King's College, Strand, London WC2R 2LS, England

关键词: Calcium;    Exocytosis;    Secretion;    Catecholamine;    Phorbol ester;    Protein kinase C;   

DOI  :  10.1016/0014-5793(83)80944-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposure of ‘leaky’ bovine adrenal medullary cells to the phorbol ester TPA causes a shift in the calcium-activation curve to lower calcium concentrations without altering the levels of secretion at the extremes of the activation curve. These results are consistent with a role for protein kinase C in exocytosis.

【 授权许可】

Unknown