Enzyme‐enzyme interactions and their metabolic role

FEBS Letters

Srere, Paul A.²  Ovadi, Judit¹ 

[1] Institute of Enzymology, Biological Research Center. Hungarian Academy of Sciences 1518, Budapest PO Box 7, Hungary;Veterans Administration Medical Center, 4500 S. Lancaster Rd, and The University of Texas Southwestern Medical Center, Dallas, TX 75216 USA

关键词: Enzyme-enzyme interaction;    Channeling;    Metabolic complex: Metabolic control theory;   

DOI  :  10.1016/0014-5793(90)81286-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

There are continuing reports on the existence of complexes of sequential metabolic enzymes. New techniques for their detection have been described and include affinity electrophoresis and the use of anti-idiotypic antibodies. Channeling of substrates has been reported for several systems as well as direct substrate transfer through dynamic enzyme associations. Kinetic parameters of metabolic control of organized systems have been formulated and tested in several systems. These recent results are expanding our understanding of metabolic processes and their control.

【 授权许可】

Unknown