Enhanced synthesis of heat shock proteins and augmented thermotolerance after induction of differentiation in HL‐60 human leukemia cells

FEBS Letters

Nishimura, Junji¹  Ideguchi, Hiroshi¹  Nawata, Hajime¹  Yufu, Yuji¹ 

[1] Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan

关键词: Heat shock protein;    Differentiation;    Thermotolerance;    HL-60 cell;   

DOI  :  10.1016/0014-5793(90)81001-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of the induction of differentiation were investigated on the expression of heat shock proteins (hsps) and thermotolerance. The synthesis of the major hsps in response to heat stress was markedly enhanced in HL-60 human leukemia cells after differentiation. An increased amount of mRNA transcripts for hsp70 was also noted. In addition, induction of differentiation resulted in acquisition of greater resistance to heat, which may be advantageous since cells in the peripheral blood must survive many stresses.

【 授权许可】

Unknown