Regulation of the level of uncoupling protein in brown adipose tissue by insulin requires the mediation of the sympathetic nervous system

FEBS Letters

Géloën, Alain¹  Trayhurn, Paul¹ 

[1] Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, UK

关键词: Brown adipose tissue;    Insulin;    Uncoupling protein;    Diabetes;    Sympathetic nervous system;    Noradrenaline;   

DOI  :  10.1016/0014-5793(90)80941-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The role of the sympathetic nervous system in the regulation by insulin of the level of uncoupling protein in brown adipose tissue has been examined. The amount of uncoupling protein was substantially reduced in streptozotocin-diabetic rats, while insulin replacement to diabetic animals induced a partial restoration. Unilateral denervation of the interscapular brown fat pads also lowered the amount of uncoupling protein, and in diabetic animals inhibited the stimulation of the level of the protein by insulin replacement. Maintenance of normal uncoupling protein levels requires both insulin and the sympathetic system; regulation of the protein by insulin involves sympathetic mediation.

【 授权许可】

Unknown