Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis

FEBS Letters

Witzemann, Veit¹  Fuchs, Sara²  Asher, Orna²  Neumann, Drorit² 

[1] Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Heidelberg, FRG;Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Adult and embryonic acetylcholine receptor;    Experimental autoimmune myasthenia gravis;    Subunit transcript;   

DOI  :  10.1016/0014-5793(90)80932-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α-, β-, ϵ-, and δ-subunit specific mRNAs (5.2-, 1.6-, 3.2- and 3.7-fold, respectively), which code for the adult type of AChR (α₂βϵδ) was observed in EAMG in rats. The γ-subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.

【 授权许可】

Unknown