High mobility group proteins 1 and 2 bind preferentially to brominated poly(dG‐dC)·poly(dG‐dC) in the Z‐DNA conformation but not to other types of Z‐DNA

FEBS Letters

Hobi, R.¹  Christen, T.¹  Bischoff, M.¹  Kuenzle, C.C.¹ 

[1] Instititut für Pharmakologie und Biochemie, Universität Zürich-Irchel, Winterthurerstr. 190, CH-8057 Zürich, Switzerland

关键词: Z-DNA;    Z-DNA-binding protein;    High mobility group protein;   

DOI  :  10.1016/0014-5793(90)80308-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Three proteins from bull testis, previously thought to be Z-DNA-binding proteins but recently found to recognize brominated poly(dG-dC)·poly(dG-dC) by criteria different from the Z-conformation, were partially sequenced. Of these, the 31 kDa protein was identified as a member of the high mobility group 2 protein family, and the 33 kDa protein as a member of the high mobility group 1 protein family. Both proteins had molecular weights approximately 30% higher than expected, indicating considerable posttranslational modification. In contrast, the 58 kDa protein remained unidentified for lack of any significant homology with known protein sequences.

【 授权许可】

Unknown