Replication‐linked histone acetylation in rat liver tissue is sensitive to alkylating agents

FEBS Letters

Talasz, Heribert¹  Weiss, Günter¹  Puschendorf, Bernd¹ 

[1] Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria

关键词: Histone;    Acetylation;    Replication;    Hepatoma;    Alkylating agent;   

DOI  :  10.1016/0014-5793(90)80785-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of alkylating agents on histone acetyltransferase (EC 2.3.1.48) activity and thymidine incorporation was investigated in benign and malignant proliferating rat liver tissue and compared with the effect in normal non-proliferating rat liver tissue. In both, benign and malignant proliferating tissue, but not in quiescent tissue, the histone acetylation is depressed by alkylating agents and this depression correlates with the inhibition of the thymidine incorporation. This effect suggests that the depression of the replication associated histone acetylation may be an important factor for the antiproliferative activity of alkylating agents.

【 授权许可】

Unknown