The maximum of the histone acetyltransferase activity precedes DNA‐synthesis in regenerating rat liver

FEBS Letters

Weiss, Günter¹  Puschendorf, Bernd¹ 

[1] Institut für Medizinische Chemie und Biochemie der Universität Innsbruck, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria

关键词: Histone;    Acetylation;    DNA replication;    H1° histone;    Regenerating rat liver;   

DOI  :  10.1016/0014-5793(88)80257-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A pronounced transitory increase of histone acetyltransferase (EC 2.3.1.48) activity before the onset of DNA replication is shown to occur in regenerating rat liver. This effect is followed by an increase in the H1/H1° ratio at the start of DNA synthesis; H1° is replaced by H1. Histone acetylation and H1/H1° exchange are discussed as steps in the signal transduction for DNA replication.

【 授权许可】

Unknown