Differential regulation of prostatic protein kinase C isozymes by androgens

FEBS Letters

Goueli, Said A.¹ 

[1] Cellular and Molecular Biochemistry Laboratory (151) and Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, and U.S. Department of Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA

关键词: Ca2+/phospholipid-dependent protein kinase;    Ca2+/phospholipid-dependent protein kinase isozyme;    Ventral prostate;    Androgen;   

DOI  :  10.1016/0014-5793(90)80762-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Multiple isozymes of Ca²⁺/phospholipid-dependent protein kinase (PKC) were isolated from the rat ventral prostate. The enzyme exists mainly as type II (β), and type III (α) forms, and it is possible that type II isozyme may comprise the subspecies β₁ and β₂. The total and specific activities of prostatic PKC isoforms were reduced in castrated animals; this decrease was specific since administration of androgens to castrated animals reversed such a decline. Also, there was a differential response to androgen deprivation so that type III isozyme declined at a faster rate than that of type II. Thus, our studies show for the first time that PKC of the rat ventral prostate comprises multiple isozymes, and that the activity of these various forms are differentially regulated by androgens.

【 授权许可】

Unknown