Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus

FEBS Letters

Sato, Kazuki²  Kobayashi, Jun'ichi²  Ohizumi, Yasushi²  Shimonishi, Yasutsugu¹  Nakamura, Hideshi²  Hidaka, Yuji¹ 

[1] Institute for Protein Research, Osaka University, Suita, Osaka 565, Japan;Mitsubishi-kasei Institute of Life Sciences, Machida-shi, Tokyo 194, Japan

关键词: Geographotoxin;    Synthesis;    Disulfide pairing;    Na+ channel;   

DOI  :  10.1016/0014-5793(90)80756-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The three intramolecular disulfide linkages of geographutoxin I, a peptidic neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986–1994]. The disulfide bridges were found to be between Cys³ and Cys¹⁵, Cys⁴ and Cys²⁰, and Cys¹⁰ and Cys²¹, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.

【 授权许可】

Unknown