A conserved cleavage‐site motif in chloroplast transit peptides

FEBS Letters

Gavel, Ylva¹  von Heijne, Gunnar² 

[1] Research Group for Theoretical Biophysics, Department of Theoretical Physics, Royal Institute of Technology, S-100 44 Stockholm, Sweden;Department of Molecular Biology, Karolinska Institute Center for Biotechnology, NOVUM, S-141 52 Huddinge, Sweden

关键词: Protein targeting;    Protein import;    Chloroplast;    Transit peptide;    Stromal protease;   

DOI  :  10.1016/0014-5793(90)80614-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A collection of 32 stroma-targeting chloroplast transit peptides with known cleavage sites have been analysed in terms of amino acid preferences in the vicinity of the processing site. A loosely conserved consensus motif (Val/Ile)-X-(Ala/Cys)↓Ala is found in the majority of the transit peptides. About 30% of the sequences have a perfect match to the consensus. When such a match is found, there is a 90% probability that it specifies the correct cleavage site.

【 授权许可】

Unknown