One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta

FEBS Letters

Onda, Haruo¹  Kimura, Chiharu¹  Matsumoto, Hirokazu¹  Ohkubo, Shoichi¹  Kosaka, Takuo¹  Ogi, Kazuhiro¹  Suzuki, Nobuhiro¹  Fujino, Masahiko¹ 

[1] Tsukuba Research Laboratories, Takeda Chemical Industries Ltd, Wadai 7, Tsukuba-shi, Ibaraki 300-42, Japan

关键词: Human endothelin 3;    cDNA cloning;    Gene expression;    (Human placenta;    COS-7 cells);   

DOI  :  10.1016/0014-5793(90)80583-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA encoding human endothelin 3 (ET-3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET-3 cDNA was found to contain 2.3 kb pairs and encode prepro-ET-3 protein consisting of 224 amino acid residues. The putative big-ET-3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET-3 gene. This is the first direct evidence that the ET-3 gene is transcribed and expressed in the placenta.

【 授权许可】

Unknown