Effect of insulin on glucose transporter distribution in white fat cells from hypophysectomized rats

FEBS Letters

Zapf, Juergen¹  Keller, Susanne¹ 

[1] Metabolic Unit, Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland

关键词: Insulin;    Hypophysectomy;    Fat cell;    Glucose transporter;    Cytochalasin B;   

DOI  :  10.1016/0014-5793(89)81525-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose transport in white fat cells from hypophysectomized rats is increased and unresponsive to insulin. The goal of this study was to explain this observation. The number of glucose transporters, as determined by D-glucose-inhibitible cytochalasin B binding, in the plasma membranes from fat cells of hypophysectomized rats is: (1) elevated, (2) not increased by insulin, and (3) the same as in plasma membranes from insulin-stimulated fat cells of control rats. In microsomal membranes from fat cells of hypophysectomized rats the number of glucose transporters is: (1) smaller than in basal and insulin-stimulated fat cells from control rats, and (2) not changed by insulin.

【 授权许可】

Unknown