Enhancement of colony forming ability in the lung by transfer of the v‐fos oncogene into a ras‐transformed rat 3Y1 cell line

FEBS Letters

Taniguchi, Shun'ichiro²  Kimura, Genki¹  Baba, Tsuneo²  Nakamatsu, Kohji² 

[1] Department of Virology, Medical Institute of Bioregulation, Kyushu University 69, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan;Department of Experimental Cell Research Fukuoka 812, Japan

关键词: Fos oncogene;    Lung metastasis;    DNA transfer;    Growth;    Ras oncogene;    Cell line;    3Y1;   

DOI  :  10.1016/0014-5793(89)81587-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transfer of the v-fos oncogene into a rat 3Y1 cell line transformed by v-H-ras, which is tumorigenic but non-metastatic, enhanced lung metastasis, depending on the amount of fos-related transcripts. Enhancement of the metastatic potential was associated with increases in tumor growth rate i.m. of inoculated cells but not the rate of in vitro cell growth, irrespective of the addition of tissue (e.g. lung) extract to the regular medium. These results suggest that the v-fos oncogene increased the malignancy by altering biological factors of the recipient cells responsible for cell growth and/or survival rate in vivo.

【 授权许可】

Unknown