A theoretical study of the acidification of the rhinovirus capsid

FEBS Letters

Warwicker, J.¹ 

[1] Department of Molecular Biophysics and Biochemistry and the Howard Hughes Medical Institute, Yale University, New Haven, CT 06511, USA

关键词: Viral uncoating;    Electrostatic modeling;    pH dependence;    Picornavirus;    Histidine residue;   

DOI  :  10.1016/0014-5793(89)81582-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none.

【 授权许可】

Unknown