Two different forms of endothelin receptors in rat lung

FEBS Letters

Masuda, Yasushi²  Watanabe, Hirotoshi²  Miyazaki, Hitoshi²  Kondoh, Motohiro²  Masaki, Tomoh¹  Murakami, Kazuo²  Yanagisawa, Masashi¹ 

[1] Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305, Japan;Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305 Japan

关键词: Endothelin;    Endothelin receptor;    Receptor subtype;    Affinity labelling;   

DOI  :  10.1016/0014-5793(89)81535-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with ¹²⁵I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.

【 授权许可】

Unknown