Three apparent receptor subtypes for the endothelin/sarafotoxin family

FEBS Letters

Bdolah, A.²  Bousso-Mittler, D.¹  Kloog, Y.¹  Sokolovsky, M.¹ 

[1] Laboratory of Neurobiochemistry, Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;Department of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

关键词: Sarafotoxin;    Endothelin;    Receptor subtype;    (Rat;    Brain;    Aorta;    Heart;    Uterus);    SRTX;    sarafotoxin;    ET;    endothelin;    E-Sα;    a high-affinity ET-1/SRTX-b subtype;    E-Sβ;    a high-affinity SRTX-c subtype;    E-Sγ;    subtype that binds all of the peptides under investigation with high affinity;   

DOI  :  10.1016/0014-5793(89)80958-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Competition binding experiments performed with ¹²⁵I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existence of three receptor subtypes: a high-affinity ET-1/SRTX-b subtype typical of smooth muscle (E-S_α receptor), a high-affinity SRTX-c subtype typical of the cerebellum (E-S_β receptor), and a less selective subtype typical of the caudate putamen that binds all of these peptides with high affinity (E-S_γ receptor).

【 授权许可】

Unknown