Kinetic and cross‐linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum

FEBS Letters

Galron, Ronit¹  Kloog, Yoel¹  Wollberg, Zvi²  Sokolovsky, Mordechai¹  Bdolah, Avner²  Kochva, Elazar² 

[1] Laboratory of Neurobiochemistry, Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel;Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6698, Israel

关键词: Receptor subtype;    Endothelin-1;    Endothelin-3;    Rate of dissociation;    Affinity labeling;    Brain;    Peripheral;    Sarafotoxin;   

DOI  :  10.1016/0014-5793(91)80542-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different issues support these conclusions.

【 授权许可】

Unknown