Secretion of Endothelin by Avascular Amnion Tissue: Possible Roles in H Pregnancy

Endocrine Journal

YOSHIHIRO OGAWA¹  MASAAKI HASEGAWA³  TAKAHIDE MORI³  KAZUWA NAKAO¹  TAKAAKI YOSHIMASA¹  GOTARO SHIRAKAMI¹  YOSHIYUKI IHARA³  HIROAKI ITOH³  JURI YANO²  NORIMASA SAGAWA³ 

[1] Second Division Department of Medicine, Kyoto University Faculty of Medicine;Department of Obstetrics and Gynecology, Ehime University School of Medicine;Department of Obstetrics and Gynecology, Kyoto University Faculty of Medicine

关键词: Amnion;    Endothelin;    Endothelin receptor;    Pregnancy;    Uterus;   

DOI  :  10.1507/endocrj.41.Supplement_S117

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(53)Cited-By(2)Endothelin (ET) was originally isolated from culture medium of porcine aortic endothelial cells as a potent vasoconstrictor peptide.Subsequently, ET was also reported to be produced by nonvascular tissues and to be involved in various biological phenomena in these tissues.Recently, a high concentration of ET-1-like immunoreactivity (ET-1-LI) was found in human amniotic fluid.Amnion tissue also contained a large amount of ET-1-LI, and cultured amnion cells secreted large amounts of ET-1-LI.The major component of ET-1-LI in these samples was ET-1.Moreover, the expression of prepro-ET-1 mRNA was detected in both amnion tissue and cultured amnion cells, indicating that ET-1 in the amniotic fluid originated from amnion cells.In cultured amnion cells, ET-1 secretion was stimulated by EGF, TGF-β, IL-1α, β and TNF-a.In addition, specific receptors for ET, ET-AR and ET-BR were detected in myometrium, decidua vera, chorion laeve, and placenta at term by both ligand binding and Northern blot analysis.These findings suggest that ET-1 secreted from amnion cells plays a physiological role in human pregnancy.In this paper, the regulation of production of ET-1 and expression of receptors for ET-1 by avascular human amnion tissue are reviewed.The possible importance of amniotic ET in human pregnancy is also discussed.

【 授权许可】

Unknown