Heterogeneous activation of protein kinase C during rat liver regeneration induced by carbon tetrachloride administration

FEBS Letters

Sato, Nobuhiro¹  Kamada, Takenobu¹  Sasaki, Yutaka¹  Hayashi, Norio¹  Ito, Toshifumi¹  Fusamoto, Hideyuki¹ 

[1] First Department of Medicine, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan

关键词: Protein kinase C;    Liver regeneration;    Carbon tetrachloride administration;    DNA synthesis;    PKC;    protein kinase C;    CCl4;    carbon tetrachloride;    BrdU;    bromo-deoxyuridine;    CLV;    centrilobular vein;    PV;    portal vein;   

DOI  :  10.1016/0014-5793(89)81009-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase C α subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase C α subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing the protein kinase C α subspecies was roughly coincident with that of hepatocytes exhibiting DNA synthesis. These results suggest that protein kinase C may play a crucial role in liver regeneration.

【 授权许可】

Unknown