Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events

FEBS Letters

Ortiz, Marcela¹  de Alzaga, Maria Gomez¹  de Asua, Luis Jimenez¹  Goin, Mercedes¹ 

[1] Instituto de Investigaciones en Ingenieria Genética y Biología Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina

关键词: Insulin;    TGFβ1;    Protein kinase C;    DNA synthesis;    OAG;    1-oleoyl-2-acetyglycerol;    PGE1;    prostaglandin E1;    PGF2α;    prostaglandin F2α;    PKC;    protein kinase C;    TGFβ1;    trans-forming growth factor β1;   

DOI  :  10.1016/0014-5793(94)01223-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F_2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E₁ (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events.

【 授权许可】

Unknown