Synergistic stimulatory effect of glucagon‐like peptide‐1 (7–36) amide and glucose‐dependent insulin‐releasing polypeptide on the endocrine rat pancreas

FEBS Letters

Trautmann, M.E.¹  Fehmann, H.-C.¹  Göke, B.¹  Göke, R.¹  Arnold, R.¹ 

[1] Department of Internal Medicine, Philipps University of Marburg, Baldingerstr., D-3550 Marburg, FRG

关键词: Incretin;    Glucagon-like peptide-1 (7–36)amide;    Glucose-dependent insulin-releasing polypeptide;    Insulin secretion;   

DOI  :  10.1016/0014-5793(89)80899-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The interaction of glucagon-like peptide-1 (7–36)amide (GLP-1) and glucose-dependent insulin-releasing polypeptide (GIP) on insulin release from the perfused rat pancreas was studied. The GLP- 1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory answer was enhanced by GIP (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. This effect was maximal at 1 nmol/l GIP and smaller but still significant at 0.1 nmol/l GIP. The high GIP concentration of 10 nmol/l GIP did not further increase insulin secretion compared to the stimulation by 1 nmol/l GIP. Our data demonstrate an additive synergistic effect of GLP- 1 and GIP on the glucose-induced insulin release. This supports the concept of an action ‘in concert’ of gastrointestinal incretin hormones postprandially released on the endocrine pancreas to guarantee adequate insulin answers after meals.

【 授权许可】

Unknown