Caldesmon150, caldesmon77 and skeletal muscle troponin T share a common antigenic determinant

FEBS Letters

Gusev, Nikolai B.²  Biryukov, Konstantin G.¹  Vorotnikov, Alexander V.²  Shirinsky, Vladimir P.¹ 

[1] Institute of Experimental Cardiology, USSR Cardiology Research Center, USSR Academy of Medical Sciences, Moscow 121552 USSR;Department of Biochemistry, School of Biology, Moscow State University, Moscow 119899, USSR

关键词: Caldesmon;    Troponin T;    Immunological cross-reactivity;    (Chicken gizzard;    Rabbit skeletal muscle;    Bovine cardiac muscle);   

DOI  :  10.1016/0014-5793(89)81429-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Caldesmon and troponin are known to control actin-myosin interaction in smooth and striated muscle. We showed that polyclonal antibodies to smooth muscle caldesmon₁₅₀ cross-react with non-muscle caldesmon₇₇ and with skeletal muscle troponin T. The epitope recognized by caldesmon antibodies is located in the CB 2 peptide [residues 71–151] of troponin T. It is supposed that the observed cross-reactivity is due to the common structure of the tropomyosin-binding site of caldesmon and troponin T.

【 授权许可】

Unknown