Characterization of cDNA clones encoding two putative isoforms of the α1 subunit of the dihydropyridine‐sensitive voltage‐dependent calcium channel isolated from rat brain and rat aorta

FEBS Letters

Shull, Gary E.²  Schwartz, Arnold¹  Koch, Walter J.¹  Ellinor, Patrick¹  Hui, Anna¹ 

[1] Department of Pharmacology and Cell Biophysic, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0575, USA;Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0575, USA

关键词: Ca2+ channel;    voltage-dependent;    Subunit;    α1;    mRNA;    cDNA clone;    Ca2+ antagonist;   

DOI  :  10.1016/0014-5793(89)80761-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

cDNA clones encoding rat brain and rat aorta isoforms of the α₁ subunit of the dihydropyridine-sensitive, voltage-dependent calcium channel were isolated and sequenced. These tissue-specific cDNA clones share significant amino acid similarity with the rabbit skeletal muscle calcium channel α₁ subunit (75% and 66% amino acid identity for rat brain and rat aorta isoforms, respectively). Northern analysis revealed transcript sizes of 6.5 and 8.6 kb in aorta and 8.6 kb in brain.

【 授权许可】

Unknown