Structures and functions associated with the group of mammalian lectins containing collagen‐like sequences

FEBS Letters

Reid, Kenneth B.M.¹  Thiel, Steffen¹ 

[1] Institut for Medicinsk Microbiologi, J.B. Winsløwsvej 19, 5000 Odense C, Denmark

关键词: Complement;    Collagen-like structure;    Clq;    Structural comparison;    Lectin;    Complement lectin interaction;    ELAM-1;    endothelial leukocyte adhesion molecule 1;    GMP-140;    granule membrane protein of 140 kDa;    gp120;    gp12O envelope protein of human immunodeficiency virus;    MBP;    mannan binding protein;    MEL-14 antigen;    mouse lymph node homing receptor;    HIV-1;    human immunodeficiency virus type 1;    IGF-II receptor;    insulin-like growth factor II receptor;    SP-A;    pulmonary surfactant apoprotein;   

DOI  :  10.1016/0014-5793(89)80689-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The number of proteins found in body fluids and at cell surfaces, which are known to display carbohydrate-binding properties, continues to increase rapidly. In these proteins, in addition to a domain associated with lectin properties, one or more, non-lectin domains are present. It is possible that binding of sugar residues by the lectin domain may be important in triggering a variety of recognition and clearance mechanisms via the non-lectin domains. The group of lectins containing collagen-like sequences may provide some insight into structure/function relationships of the different domains in view of the well defined structures already available for several of these molecules.

【 授权许可】

Unknown