Induction of tumour hypoxia by a vasoactive agent A combined NMR and radiobiological study

FEBS Letters

Dunn, J.F.¹  Frostick, S.¹  Hogan, G.¹  Howells, N.²  Stratford, I.J.²  Radda, G.K.¹  Adams, G.E.² 

[1] MRC Biochemical & Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford England;MRC Radiobiology Unit, Chilton, Didcot, England

关键词: Hydralazine;    NMR;    Tumor;    Chemotherapy;   

DOI  :  10.1016/0014-5793(89)80655-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of hydralazine treatment on 3 murine tumours (RIF-1, KHT and 16/C) was monitored using ³¹P-NMR. Changes in the ³¹P-NMR spectrum are compared with measurements of radiobiological hypoxic fraction (RHF) in the RIF-1 and KHT. Hydralazine is known to reduce temporarily blood flow in experimental tumours, and thus cause a transient increase in the RHF to 100% (in RIF-1 and KHT). This correlates with a decline in energy status as measured by ³¹P-NMR (i.e. there was an increase in P_i in all three tumours). Time-course data from the RIF-1 and KHT tumours show that maintenance of anaesthesia prolongs the hypoxia induced by hydralazine.

【 授权许可】

Unknown