Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor‐α

FEBS Letters

Carpinelli, G.²  Podo, F.²  Proietti, E.²  Belardelli, F.²  Bravo, E.¹  Cantafora, A.¹ 

[1] Laboratories of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy;Laboratories of Cellular Biology and Virology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

关键词: Tumor;    Tumor necrosis factor;    Friend erythroleukemia cell;    Phospholipid;    Glycerolipid;    Free fatty acid;    FLC;    Friend erythroleukemia cells;    TNF-α;    tumor necrosis factor-α;    IL-1 β;    interleukin-1 β;    GroPCHo;    glycerol 3-phosphorylcholine;    GroPEtn;    glycerol 3-phosphorylethanolamine;    PCho;    phosphorylcholine;    PEtn;    phosphorylethanolamine;    GroP;    sn-glycerol 3-phosphate;    Cho;    choline;    PL;    phospholipids;    PC;    phosphatidylcholine;    PE;    phosphatidylethanolamine;    PS;    phosphatidylserine;    SPM;    sphingomyelin;    FFA;    free fatty acids;    DG;    diglycerides;    TG;    triglycerides;    HPTLC;    high performance thin layer chromatography;    NMR;    nuclear magnetic resonance;   

DOI  :  10.1016/0014-5793(90)80108-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipid analyses were carried out on transplantable murine Friend leukemia cell tumors, 6 h after intratumoral administration of tumor necrosis factor-α (TNF). The levels of the major phospholipid classes were uniformly decreased to about 70% of control values; free fatty acids were increased to about 170%; diacylglycerol was decreased to about 50% and triacylglycerol, the main lipid component, was not significantly altered. These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous ³¹P NMR studies) and histological modifications demonstrated that at early stages of TNF-induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products.

【 授权许可】

Unknown