Activation of chloride channels in the plasmalemma of Nitella syncarpa by inositol 1,4,5‐trisphosphate

FEBS Letters

Zherelova, O.M.¹ 

[1] Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino, Moscow Region 142292, USSR

关键词: Inositol 1;    4;    5-trisphosphate;    Ca2+;    Ionic channel;    (Characeae;    Nitella syncarpa);   

DOI  :  10.1016/0014-5793(89)80025-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The introduction of 1.5 × 10⁻⁸ − 10⁻⁶ M inositol 1,4,5-trisphosphate (IP₃) into the bathing solution of Nitella syncarpa cells induced: (i) an increase in amplitude of the inward Ca²⁺ current; (ii) the appearance of an inward Cl⁻ current; (iii) a shift in the threshold for activation of the Cl⁻ channels on hyperpolarization of the membrane to more positive values. These facts suggest that IP₃ participates in the causing of changes in the intracellular free Ca²⁺ concentration and, hence, in the regulation of ionic channels in Nitella syncarpa plasmalemma.

【 授权许可】

Unknown