Heparin inhibits the inositol 1,4,5‐trisphosphate‐induced Ca2+ release from rat liver microsomes

FEBS Letters

Cullen, Peter J.¹  Comerford, John G.¹  Dawson, Alan P.¹ 

[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England

关键词: Ca2+;    Inositol 1;    4;    5-trisphosphate;    GTP;    Heparin;    Microsome;    Polyphosphoinositide;    PEG;    poly(ethylene glycol);    M r 8000;    DTT;    dithiothreitol;   

DOI  :  10.1016/0014-5793(88)80584-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inositol 1,4,5-trisphosphate (Ins (1,4,5)P₃)-stimulated Ca²⁺ release is inhibited by low concentrations of heparin (IC₅₀=4.5 μg/ml). GTP-stimulated Ca²⁺ release is unaffected at a heparin concentration of 16 μ/ml. Addition of heparin after Ins (1,4,5)P₃ causes the rapid re-uptake of Ins (1,4,5)P₃-releasable Ca²⁺.

【 授权许可】

Unknown