期刊论文详细信息
FEBS Letters | |
Heparin inhibits the inositol 1,4,5‐trisphosphate‐induced Ca2+ release from rat liver microsomes | |
Cullen, Peter J.1  Comerford, John G.1  Dawson, Alan P.1  | |
[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England | |
关键词: Ca2+; Inositol 1; 4; 5-trisphosphate; GTP; Heparin; Microsome; Polyphosphoinositide; PEG; poly(ethylene glycol); M r 8000; DTT; dithiothreitol; | |
DOI : 10.1016/0014-5793(88)80584-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Inositol 1,4,5-trisphosphate (Ins (1,4,5)P3)-stimulated Ca2+ release is inhibited by low concentrations of heparin (IC50=4.5 μg/ml). GTP-stimulated Ca2+ release is unaffected at a heparin concentration of 16 μ/ml. Addition of heparin after Ins (1,4,5)P3 causes the rapid re-uptake of Ins (1,4,5)P3-releasable Ca2+.
【 授权许可】
Unknown
【 预 览 】
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