Distribution of serotonin 5‐HT1C receptor mRNA in adult rat brain

FEBS Letters

Hoffman, Beth J.¹  Mezey, Eva¹ 

[1] Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892, USA

关键词: Oligonucleotide;    Hybridization;    5-HT;    5-hydroxytryptamine;    serotonin;    ISHH;    in situ hybridization histochemistry;    CNS;    central nervous system;   

DOI  :  10.1016/0014-5793(89)81390-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Based on in situ hybridization histochemistry (ISHH), we describe the anatomical distribution of the serotonin 5-HT_1C receptor mRNA. In addition to the very high levels in epithelial cells of the choroid plexus, 5-HT_1C receptor mRNA is found throughout the limbic system, in catecholaminergic cells and in serotonergic neurons. Receptor transcripts are also present in the hypothalamus, numerous motor nuclei and the subthalamus. Our results correlate well with serotonin (5-HT) innervation and receptor binding. Receptor mRNA is present in many brain structures in addition to regions previously shown to have 5-HT_1C receptor binding. The distribution of this receptor mRNA suggests that the 5-HT_1C receptor may mediate a number of the central effects of 5-HT.

【 授权许可】

Unknown