Differential activities of two distinct endothelin family peptides on ileum and coronary artery

FEBS Letters

Mitsui, Youji²  Ishida, Norio²  Saida, Kaname²  Tsujioka, Keiji¹  Tomoi, Masaaki¹ 

[1] Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd, Kashima, Yodogawa-ku, Osaka 532, Japan;Cell Science and Technology Division, Fermentation Research Institute, Agency of Industrial Science and Technology, Higashi 1-1-3, Tsukuba Science City, Ibaraki 305 Japan

关键词: Vasoactive intestinal contractor;    Endothelin family;    Intestine contraction;    Ca2+;    extracellular;    Gastrointestinal hormone;    VIC;    vasoactive intestinal constrictor;    ET;    endothelin;    Ach;    acetylcholine;   

DOI  :  10.1016/0014-5793(89)81365-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A synthesized mouse vasoactive intestinal contractor peptide, which belongs to a novel member of the endothelin family, induced a prolonged contraction in mouse ileum as well as porcine coronary artery in vitro. Studies comparing the effects of vasoactive intestinal contractor and endothelin on different tissues revealed that the maximum ileum contraction of vasoactive intestinal contractor was much higher than that of endothelin in both guinea pig and mouse systems, but that the vasoconstriction activity of vasoactive intestinal contractor was weaker than that of endothelin in porcine artery. These resuts show that vasoactive intestinal contractor might be a novel gastrointestinal hormone.

【 授权许可】

Unknown