Vinblastine sensitivity of leukaemic lymphoblasts modulated by serum lipid

FEBS Letters

Tripp, Edith¹  Dyne, Marlen¹  Mountford, Carolyn E.¹  Wright, Lesley C.¹  May, George L.¹  Williams, Philip G.¹  Holmes, Kerry T.¹ 

[1] Department of Cancer Medicine and Ludwig Institute for Cancer Research (Sydney Branch), Blackburn Building, University of Sydney, Sydney, NSW 2006, Australia

关键词: Vinblastine;    Drug resistance;    NMR;    1H-;    Lipid content;    (Leukemic lymphoblast);   

DOI  :  10.1016/0014-5793(89)81172-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The high-resolution proton magnetic resonance spectrum of leukaemic lymphoblasts is characteristic of neutral lipid in an isotropic environment. When such lymphoblasts are selected for resistance to the anticancer drug vinblastine, the intensity of this spectrum increases with increasing drug resistance. A reversal of this trend can be achieved by growing cells in delipidated serum, whereby lipid spectrum and drug resistance are diminished. However, both can be restored by subsequent regrowth in normal medium. Thus, although detectable genetic changes accompany the development of vinblastine resistance, the expression of these changes can be modulated by environmental lipid.

【 授权许可】

Unknown