The interaction of β‐N‐methylamino‐L‐alanine with bicarbonate: an 1H‐NMR study

FEBS Letters

O'Brien, Paul²  Nunn, Peter B.¹ 

[1] Department of Biochemistry, King's College London, Strand, London WC2R 2LS, England;Department of Chemistry, Queen Mary College, Mile End Rd, London E1 4NS, England

关键词: Methylamino-L-alanine;    β-N-;    Bicarbonate;    Carbamate;    NMR;    1H-;    Methyl-D-aspartate;    N-;   

DOI  :  10.1016/0014-5793(89)81423-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mode of action of the neurotoxic, non-protein amino acid β-N-methylamino-L-alanine (L-BMAA) is unknown. We have shown, using ¹H-NMR spectroscopy, that L-BMAA forms a stable adduct with bicarbonate (probably a carbamate). The properties of this adduct may explain the observation that L-BMAA and N-methyl-D-aspartic acid appear to act at the same central nervous system receptors.

【 授权许可】

Unknown