Synthesis of Bis-ureas from Bis(o-nitrophenyl) Carbonate

Molecules

Maria-Cristina Turoczi¹  Monika Simon²  Valentin Badea² 

[1] id="af1-molecules-13-03192">“ POLITEHNICA” University of Timisoara, Department of Applied Chemistry and Engineering of Organic and Natural Compounds, 300006 Timisoara, Piata Victoriei 2, Roman

关键词: Bis(o-nitrophenyl) carbonate;    Carbamate;    Bis-urea;   

DOI  :  10.3390/molecules13123192

来源: mdpi

【 摘 要 】

A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of diamines in toluene to yield bis-ureas.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.