期刊论文详细信息
FEBS Letters | |
Cleavage of specific sites of RNA by designed ribozymes | |
Iwai, Shigenori1  Ohtsuka, Eiko1  Koizumi, Makoto1  | |
[1] Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan | |
关键词: Synthetic oligoribonucleotide; RNA enzyme; Endonucleolytic activity; RNA sequence recognition; | |
DOI : 10.1016/0014-5793(88)80935-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Two ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially paired oligoribonucleotides with chain lengths of 19 and 15. The other ribozyme, which consists of a 19-mer and a 13-mer, recognized a UC sequence at positions 42 and 43 of 5 S rRNA.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020291250ZK.pdf | 522KB | download |